The cytocidal action of normal human serum on Ehrlich Lettré ascites tumor cells. II. Biochemical studies.
نویسندگان
چکیده
Incubation of Ehrlich Lettréascites tumor cells with normal human serum at 37°C\vas found to result in the loss of a high percentage of cellular acid-soluble ribonucleotides, a decrease in lactic acid production, and a lower rate of endogenous respiration than in controls. Oxidation of succinate, a-glycerophosphate, and a-ketoglutarate was stimulated in cells preincubated in nor mal human serum. Furthermore, it was possible to obtain respi ratory stimulation with adenosine-5'-diphosphate with several
منابع مشابه
A cytocidal system in normal human serum active against Ehrlich Lettré ascites tumor cells. I. Identification of the components of the system and site of attachment.
The natural cytocidal system in normal human serum active against Ehrlich Lettréascites tumor cells was found to involve serum complement and /3-globulin. While all 4 components of complement were found to be required in order for the cytocidal action to be expressed, only C'4 was necessary for the attach ment of the /3-globulin to the tumor cell. Adsorption of the serum with cells from primar...
متن کاملCytocidal effect of rifamycin derivatives on ascites tumor cells: studies with [125I]iododeoxyuridine.
The cytotoxicity of 2 rifamycin derivatives, rifazone-82 and rifampicin, on mouse ascites cells was studied, using the [125I]iododeoxyuridine (IUDR) method of labeling the tumor cells. This technique allows a distinction to be made between a cytocidal and cytostatic effect. The 2 drugs exerted a cytocidal effect against 2 non-leukemic cell lines, but had no effect against 3 leukemic lines.
متن کاملAntitumor Activity of Prosopis glandulosa Torr. on Ehrlich Ascites Carcinoma (EAC) Tumor Bearing Mice
The antitumor activity of ethanol extract of Prosopis glandulosa Torr. (EPG) was evaluated against Ehrlich ascites carcinoma (EAC) tumor model in Swiss albino mice on dose dependent manner. The activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumor volume. Oral administration of EPG at the dose of 100, 200 and 400 mg/Kg, significantl...
متن کاملAntitumor Activity of Prosopis glandulosa Torr. on Ehrlich Ascites Carcinoma (EAC) Tumor Bearing Mice
The antitumor activity of ethanol extract of Prosopis glandulosa Torr. (EPG) was evaluated against Ehrlich ascites carcinoma (EAC) tumor model in Swiss albino mice on dose dependent manner. The activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumor volume. Oral administration of EPG at the dose of 100, 200 and 400 mg/Kg, significantl...
متن کاملInvestigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created
Objective(s): In this study, the effects of different doses of curcumin application on Ehrlich ascites tumor (EAT) created in the mice of BALB/c type were investigated.Materials and Methods: Curcumin extracts can have hindering effect on tumor volume, vascular density, EAT cells around the tissues, and can support apoptosis. EAT cells (1x106) received from stock animals were injected intraperit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cancer research
دوره 27 1 شماره
صفحات -
تاریخ انتشار 1967